Pragma Journal

GLP-1 & weight

The four lifestyle levers most affecting your weight in your 40s (none of them are berberine)

The "everything I'm doing right stopped working" wall in your 40s is real, and it's not a metabolism that broke. Four levers explain most of it: muscle, protein, sleep and cortisol, and blood sugar. Here's the honest order to pull them.

Whitney Brooke Isola, MBA, RDN · July 27, 2026 · 6 min read

GLP-1 & weight

GLP-1 Nutrition: Learn the basics

GLP-1 medications have predictable nutritional consequences: muscle loss, micronutrient gaps, hair shedding. Here's how to handle the nutrition side without fighting the medicine. Doses, protein math, and what's worth supplementing.

Samantha Peebles, DCN, RDN · July 23, 2026 · 6 min read

GLP-1 & weight

GLP-1 and muscle loss

Up to 25-40% of weight lost on GLP-1 medications can be lean mass. Here's the protein and resistance-training math that changes that number.

Samantha Peebles, DCN, RDN · July 7, 2026 · 2 min read